Alfredo Budillon Selected Research

Colorectal Neoplasms (Colorectal Cancer)

1/2022	Plasma metabolomics, lipidomics and cytokinomics profiling predict disease recurrence in metastatic colorectal cancer patients undergoing liver resection.
1/2021	Effect of Bevacizumab in Combination With Standard Oxaliplatin-Based Regimens in Patients With Metastatic Colorectal Cancer: A Randomized Clinical Trial.
1/2020	Randomized phase II study of valproic acid in combination with bevacizumab and oxaliplatin/fluoropyrimidine regimens in patients with RAS-mutated metastatic colorectal cancer: the REVOLUTION study protocol.
12/2017	Synergistic antitumor interaction between valproic acid, capecitabine and radiotherapy in colorectal cancer: critical role of p53.
10/2016	Proteomic characterization of peroxisome proliferator-activated receptor-γ (PPARγ) overexpressing or silenced colorectal cancer cells unveils a novel protein network associated with an aggressive phenotype.
2/2016	A randomized phase 3 study on the optimization of the combination of bevacizumab with FOLFOX/OXXEL in the treatment of patients with metastatic colorectal cancer-OBELICS (Optimization of BEvacizumab scheduLIng within Chemotherapy Scheme).
7/2015	Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients.
1/2014	Targeting thymidylate synthase in colorectal cancer: critical re-evaluation and emerging therapeutic role of raltitrexed.
5/2009	Modulation of thymidilate synthase and p53 expression by HDAC inhibitor vorinostat resulted in synergistic antitumor effect in combination with 5FU or raltitrexed.
6/2008	Highlights of the annual meeting of the Italian Association for Cell Cultures (AICC): new drug delivery strategies and technological platforms for diagnosis and therapy of tumors (Part I) 6 - 7 December 2007, Naples, Italy.

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Alfredo Budillon Research Topics

Disease

76	Neoplasms (Cancer) 03/2024 - 04/2003
12	Prostatic Neoplasms (Prostate Cancer) 10/2020 - 05/2007
11	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 10/2005
10	Melanoma (Melanoma, Malignant) 05/2024 - 12/2004
9	Breast Neoplasms (Breast Cancer) 01/2022 - 06/2006
9	Rectal Neoplasms (Rectal Cancer) 11/2019 - 06/2007
8	Neoplasm Metastasis (Metastasis) 01/2022 - 05/2006
7	Squamous Cell Carcinoma of Head and Neck 01/2020 - 11/2004
6	Pancreatic Neoplasms (Pancreatic Cancer) 04/2022 - 07/2007
5	Inflammation (Inflammations) 01/2023 - 09/2017
5	Adenocarcinoma 03/2022 - 05/2007
5	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2019 - 03/2005
5	Carcinoma (Carcinomatosis) 09/2012 - 11/2004
4	Triple Negative Breast Neoplasms 01/2022 - 12/2017
4	Carcinogenesis 01/2019 - 10/2016
3	Glioblastoma (Glioblastoma Multiforme) 12/2023 - 01/2019
3	Brain Neoplasms (Brain Tumor) 01/2023 - 01/2006
3	Head and Neck Neoplasms (Head and Neck Cancer) 01/2020 - 01/2006
3	Colonic Neoplasms (Colon Cancer) 11/2016 - 10/2005
3	Bone Diseases (Bone Disease) 11/2006 - 05/2006
2	Type 2 Diabetes Mellitus (MODY) 10/2023 - 01/2014
2	Disease Progression 11/2022 - 07/2015
2	Lung Neoplasms (Lung Cancer) 09/2016 - 01/2014
1	COVID-19 03/2023
1	Cytokine Release Syndrome 03/2023

Drug/Important Bio-Agent (IBA)

18	Proteins (Proteins, Gene)FDA Link 05/2024 - 05/2007
14	Histone Deacetylase InhibitorsIBA 01/2020 - 06/2007
12	Biomarkers (Surrogate Marker)IBA 01/2024 - 09/2011
10	ErbB Receptors (EGF Receptor)IBA 12/2015 - 04/2003
8	Fluorouracil (Carac)FDA LinkGeneric 01/2019 - 10/2005
8	Zoledronic Acid (Zometa)FDA Link 09/2015 - 09/2004
7	Bevacizumab (Avastin)FDA Link 01/2021 - 09/2011
7	Valproic Acid (Depakote)FDA LinkGeneric 10/2020 - 02/2016
7	Vorinostat FDA Link 01/2019 - 05/2009
6	Cisplatin (Platino)FDA LinkGeneric 01/2020 - 01/2014
5	CytokinesIBA 03/2023 - 12/2004
5	Antineoplastic Agents (Antineoplastics)IBA 01/2022 - 07/2008
5	Messenger RNA (mRNA)IBA 01/2022 - 11/2016
5	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2021 - 10/2005
5	Histone Deacetylases (Histone Deacetylase)IBA 01/2020 - 06/2007
5	Cetuximab (Erbitux)FDA Link 01/2020 - 01/2007
5	Gefitinib (Iressa)FDA Link 12/2015 - 04/2003
5	Tyrosine Kinase InhibitorsIBA 12/2015 - 04/2003
5	Epidermal Growth Factor (EGF)IBA 09/2012 - 09/2004
4	MicroRNAs (MicroRNA)IBA 01/2024 - 07/2018
4	Leucovorin (Folinic Acid)FDA Link 10/2015 - 10/2005
4	raltitrexed (D 1694)IBA 10/2015 - 08/2007
3	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 06/2008
3	Hormones (Hormone)IBA 05/2018 - 09/2010
3	Capecitabine (Xeloda)FDA Link 12/2017 - 11/2014
3	Monoclonal AntibodiesIBA 04/2016 - 06/2006
3	EnzymesIBA 02/2016 - 03/2004
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2014 - 05/2006
3	Gemcitabine FDA Link 08/2011 - 10/2005
3	tipifarnib (R115777)IBA 11/2007 - 09/2004
2	IntegrinsIBA 03/2024 - 07/2019
2	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2024 - 10/2016
2	Transcription Factors (Transcription Factor)IBA 01/2024 - 10/2016
2	Immune Checkpoint InhibitorsIBA 10/2023 - 01/2019
2	NivolumabIBA 10/2023 - 11/2022
2	Neoplasm Antigens (Tumor Antigens)IBA 01/2023 - 12/2017
2	domatinostatIBA 04/2022 - 03/2022
2	Valosin Containing ProteinIBA 01/2022 - 09/2021
2	Selenoproteins (Selenoprotein)IBA 01/2022 - 09/2020
2	Interleukin-18 (Interleukin 18)IBA 04/2021 - 01/2021
2	PlatinumIBA 01/2021 - 01/2019
2	Docetaxel (Taxotere)FDA Link 10/2020 - 09/2010
2	Anticonvulsants (Antiepileptic Drugs)IBA 01/2020 - 02/2016
2	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 11/2019 - 12/2012
2	givinostatIBA 01/2019 - 01/2019
2	givinostat hydrochlorideIBA 01/2019 - 01/2019
2	Metformin (Glucophage)FDA LinkGeneric 01/2019 - 01/2014
2	Mevalonic Acid (Mevalonate)IBA 01/2018 - 05/2007
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2017 - 11/2009
2	Protein Glutamine gamma Glutamyltransferase 2IBA 01/2017 - 01/2013
2	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 11/2016 - 04/2008
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 10/2016 - 01/2012
2	AntibodiesIBA 07/2015 - 11/2004
2	Histones (Histone)IBA 11/2014 - 06/2007
2	Thymidylate SynthaseIBA 01/2014 - 08/2007
2	Phosphotransferases (Kinase)IBA 08/2011 - 06/2006
2	AndrogensIBA 11/2009 - 05/2007
2	TransferasesIBA 11/2007 - 09/2004
2	Diphosphonates (Bisphosphonates)IBA 11/2006 - 06/2006
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 11/2006 - 06/2006
2	Pamidronate (Aredia)FDA LinkGeneric 11/2006 - 09/2004
2	Interferon-alpha (Interferon Alfa)IBA 01/2005 - 12/2004
1	Chlorpromazine (Thorazine)FDA Link 12/2023
1	Antipsychotic Agents (Antipsychotics)IBA 12/2023
1	Pyruvate KinaseIBA 12/2023
1	relatlimabIBA 10/2023
1	Protons (Proton)IBA 03/2023
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2023

Therapy/Procedure

30	Therapeutics 12/2023 - 03/2004
18	Drug Therapy (Chemotherapy) 04/2022 - 10/2005
7	Radiotherapy 01/2020 - 03/2011
5	Immunotherapy 01/2023 - 12/2017
3	Chemoradiotherapy 11/2019 - 06/2007
2	Castration 10/2020 - 09/2010
1	Critical Care (Surgical Intensive Care) 03/2023